Welcome to a new comprehensive resource for healthcare professionals and scientists who are interested in the expanding field of HIV pharmacogenomics.
Advances in our understanding of the multitude of complex genetic relationships underlying clinical outcomes in HIV may ultimately lead to:
- Personalised treatment regimens
- Development of tools that enable HIV-treating physicians to predict clinical outcomes for their patients, for example response to antiretroviral treatment and the likelihood of drug toxicity
- Increased knowledge of basic cellular mechanisms of drug action that affect antiretroviral pharmacokinetics and pharmacodynamics.
Pharmacogenomics are of particular interest for the clinical management of HIV because of the long-term nature of therapy, the use of combination antiretroviral regimens, the high prevalence of adverse reactions and long-term drug toxicity.